Year Appointed: 1997

Qualifications:
- Dr. Bai received his Ph.D in 1992 from the Program of Biochemistry and Molecular Biology at University of Texas M. D. Anderson Cancer Center and finished his postdoctoral training in 1997 from the Department of Molecular and Cell Biology at Baylor College of Medicine.

Expertise/ Research Interests:
This laboratory focuses on the role of steroid and Vitamin D receptors in the development and treatment of human cancers. On-going research projects include the investigation of the role of the estrogen receptor (ER) in mediating the tissue-specific agonistic and antagonistic activity of Selective Estrogen Receptor Modulators (SERMs) in breast and endometrial cancer cells, the study of the functional interaction between PTEN tumor suppressor and the androgen receptor in the growth and apoptosis of prostate cancer cells, and the study of the functions of Vitamin D and its receptors in ovarian cancer development and treatment. The overall objective of the research is, through the elucidation of the mechanism of action of steroid hormones and Vitamin D in human cancer cells, to develop new therapeutic strategies for cancer patients or improve the patients’ response to existing hormonal or anti-hormone therapies.

Memberships:
- Endocrine Society
- American Association for the Advancement of Science
- FASEB
 
Publications:

1. Yonghua Yang, Wei Fu, Nancy Olashaw, Santo V. Nicosia and *Wenlong Bai. Site-specific SIRT1 sumoylation regulate its deacetylase activity and cell’s response to UV and oxidative stress. Nature Cell Biology, Being revised.
2. Junying Bao, Chuanhai Cao, Xiaohui Zhang, Feng Jiang, Santo V. Nicosia and *Wenlong Bai. Suppression of APP signaling into nucleus by estrogens mediated through the complex formation between the estrogen receptor and Fe65. Molecular and Cellular Biology, Being revised.
3. Xiaohui Zhang, Pengfei Li, Junying Bao, Santo V. Nicosia, Honggang Wang, Steven A. Enkemann and *Wenlong Bai.  (2005) Suppression of Death Receptor-mediated Apoptosis by 1,25-dihydroxyvitamin D3 Revealed by Microarray Analysis. Journal of Biological Chemistry. 280: 35458-35468.
4. Yonghua Yang, Lucy Hou, Edward Haller, Santo V. Nicosia and *Wenlong Bai. (2005) Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J 24:1021-32.
5. Xiaohui Zhang, Feng Jiang, Pengfei Li, Chunrong Li, Qiuping Ma, Santo V. Nicosia and *Wenlong Bai. (2005) Suppression of ovarian caner growth by synthetic vitamin D analog EB1089 in nude mice. Clinical Cancer Research 11: 323-328
6. Feng Jiang, Junying Bao, Pengfei Li, Santo V. Nicosia and *Wenlong Bai (2004) Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down regulation of telomerase. Journal of Biological Chemistry 279:53213-21
7. Pengfei Li, Chunrong Li, Xiuhua Zhao, Xiaohong Zhang, Santo V. Nicosia and *Wenlong Bai. (2004) p27Kip1 Stabilization and G1 Arrest by 1,25-Dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through Down Regulation of Cyclin E/CDK2 Kinase and SCF/Skp2 Ubiquitin Ligase Journal of Biological Chemistry 279:25260-7.
8. Feng Jiang, Pengfei Li, Albert J Fornace Jr, Santo V Nicosia, *Wenlong Bai (2003) G2/M Arrest by 1,25 dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through the Induction of GADD45 via an Exonic Enhancer. Journal of Biological Chemistry 278:48030-40
9. Pengfei Li, Heehyoung Lee, Shaodong Guo, Terry G. Unterman, Guido Jenster and *Wenlong Bai. (2003) AKT-independent Protection of Prostate Cancer Cell Apoptosis Mediated through Androgen-independent Complex Formation between Androgen Receptor and FKHR. Molecular and Cellular Biology 23: 104-118
10. Heehyoung Lee and *Wenlong Bai. (2002) Inhibition of Estrogen Receptor Nuclear Export by Ligand-induced and p38-mediated Receptor Phosphorylation. Molecular and Cellular Biology 22: 5835-5845