Affiliations:
Site/Title
-James A. Haley VA Hospital/ Chief,Molecular Diagnostics
Laboratory
Pathology and Cell Biology and Cell Biology Service (673/113)
James A. Haley VA Hospital
13000 Bruce B. Downs Blvd.
Tampa, FL 33647
Qualification:
- M. D.
- Board certified in Anatomic and Clinical Pathology and Cell Biology by the American Board
of Pathology and Cell Biology
Expertise/ Research Interests:
- Advanced diagnostic technologies
- My main research interest involves investigation of molecular changes
underlying prostate and urinary bladder neoplastic and non-neoplastic diseases
with special emphasis on tumor proliferation and apoptotic processes.
My recent publications on this topic are
here
Other Expertise:
- Molecular and Advanced Diagnostics
- Surgical Pathology and Cell Biology and Cytology, with special
expertise in Genitourinary and Gastrointestinal Pathology and Cell Biology.
Memberships:
- College of American Pathologists
Previous Positions:
- Assistant Professor of Pathology and Cell Biology and Urology
University of Maryland School of Medicine
22 South Greene Street, NBW43
Baltimore, MD 21201
- Acting Chief, Pathology and Cell Biology and Cell Biology Service
Maryland VA Health Care System
10 North Greene Street
Baltimore, MD 21201
Publications:
- Burke L, Flieder D.B., Guinee D.G., Brambilla E., Freedman A.N., Bennett
W.P., Jones R.T., Borkowski A., Caporaso N.A., Fleming M., Trastek
V., Pairolero P., Tazelaar H., Midthun D., Jett JR, Liotta L.A., Travis
W.D., Harris C.C. Prognostic implications of molecular and immunohistochemical
profiles of the Rb and p53 cell cycle regulatory pathways in primary
non-small cell lung carcinoma. Clin Cancer Res 2005, 11:232-41.
- Alexander, R.B., Mann D.L., Borkowski, A.A., Fernandez-Vina,
M., Klyushnenkova, E.N., Kodak, J., Propert, K.J., Kincaid, M. Granulomatous
Prostatitis Linked to HLA-DRB1*1501. J Urol 2004, 171:2326-2329.
- Kimos, M.C., Wang, S., Borkowski, A., Yang, G.Y., Perry, K.,
Olaru, A., Deacu, E., Sterian, A., Cottrell, J., Papadimitriou, J.,
Sisodia, L., Selaru, F.M., Mori, Y., Xu, Y., Yin, J., Abraham, J.M.,
Meltzer, S.J. Esophagin And Proliferating Cell Nuclear Antigen (PCNA)
Are Biomarkers of Human Esophageal Neoplastic Progression. Int J Cancer
2004, 111:415-417.
- Borkowski, A., Lee, D.H., Sydnor, D.L., Johnson, R.J., Rabinovitch,
A., Moore, G.W. Intranet-Based Quality Improvement Documentation
at the Veterans Affairs Maryland Health Care System. Modern Pathol
2001, 14:1-5.
- Winter, R.N., Kramer, A., Borkowski, A., Jacobs, S.C., Kyprianou,
N. Loss of Caspase-1 and Caspase-3 Protein Expression in Human Prostate
Cancer. Cancer Res 2001, 61:1227-32.
- Keledjian, K., Borkowski, A., Kim, G., Isaacs, J.T., Jacobs
S.C., Kyprianou, N. Reduction of Human Prostate Tumor Vascularity
by alpha 1-Adrenoceptor Antagonist Terazosin. Prostate 2001, 48:71-8.
- Glassman, D.T., Chon, J.K., Borkowski, A., Jacobs, S.C., Kyprianou,
N. Combined Effect of Terazosin and Finasteride on Apoptosis, Cell
Proliferation and Transforming Growth Factor-b Expression in Benign
Prostatic Hyperplasia. Prostate 2001, 45:1-7.
- Guo, Y., Borkowski, A., Sigman D.B., Kuprianou, N., Racial
Differences in Prostate Cancer Growth: Apoptosis and Cell Proliferation
in Caucasian and African-American Patients. Prostate 2000, 42, 130-6.
- Chon, J.K., Borkowski, A., Partin, A.W., Isaacs, J.T., Jacobs,
S.C., Kyprianou, N. a1-adrenoceptor Antagonists Terazosin and Doxazosin
Induce Prostate Apoptosis without Affecting Cell Proliferation in Patients
with Benign Prostatic Hyperplasia. J Urology 1999, 161, 2002-8.
- Del Pizzo, J.J., Borkowski, A., Jacobs, S.C., Kyprianou, N.
Loss of Cell-cycle regulators p27Kip1 and Cyclin E in Transitional Cell
Carcinoma of the Bladder Correlates with Tumor Grade and Patient Survival.
Am J Pathol 1999, 155, 1129-1136.
- Mackey, T.J., Borkowski, A., Jacobs, S.C., Amin, P., Kyprianou,
N. Bcl-2/Bax Ratio as a Predictive Marker for Therapeutic Response
to Radiation in Prostate Cancer Patients. Urology 1998, 52, 1085-1090.
- Kyprianou, N., Litvak, J.P., Alexander, R.B., Borkowski, A.,
Jacobs, S.C., Induction of Prostate Apoptosis by Doxazosin in Benign
Prostatic Hyperplasia. J Urology 1998, 159, 1810-1815.
- Bennett, W.P., El-Deiry, W.S., Guinee, D.G., Freedman, A.N., Rush,
W.L., Caporaso, N.E., Welsh, J.A., Jones, R.T., Borkowski, A.,
Travis, W.D., Fleming, M.V., Colby, T.V., Trastek, V., Pairolero, P.C.,
Tazelaar, H.F., Midthun, D., Jett, J.R., Liota, L.A., Vogelstein, B.,
Harris, C.C. p53/p21waf1/cip1 and Transforming Growth Factor-ß1
Protein Expression Correlate with Survival in Non-Small Cell Lung Cancer.
Clin Cancer Res 1998, 6, 1499-1506.
- Greenblatt, M.S., Feitelson, M.A., Zhu, M., Bennett, W.P., Welsh,
J.A., Jones, R.T., Borkowski, A., and Harris, C.C., Integrity
of p53 in Hepatitis B x Antigen-positive and -negative Hepatocellular
Carcinomas. Cancer Res 1997, 57, 426-432.
- Guo, Y., Sklar, G.N., Borkowski, A., Kuprianou, N., Loss
of the Cyclin-dependent Kinase Inhibitor p27kip1 Protein in Human Prostate
Cancer Correlates with Tumor Grade. Clin Cancer Research 1997, 3,
2269-2274.
- Tu, H., Jacobs, S.C., Borkowski, A., and Kyprianou, N., Incidence
of Apoptosis and Cell Proliferation in Prostate Cancer: Relationship
with TGF-b and bcl-2 Expression. Int J Cancer 1996, 69, 357-363.
- Sawyer, R., Berman, J.J., Borkowski, A., and Moore, G.W.,
Elevated PSA (Prostate Specific Antigen) Levels in African-American
and White Men. Modern Pathol 1996, 9, 1029-1032.
- Borkowski, A., Bennett, W.P., Jones, R.T., Borkowski, P.,
Harris, C.C., Ferreira, L.R., Kao, G.F., and Trump, B.F., Quantitative
Image Analysis of p53 Protein Accumulation in Keratoacanthomas.
Am J Dermatopathol 1995, 17, 335-338.
- Borkowski, P., Kusiak, J.W., Borkowski, A., Liu, L., Smialek,
J.E., Robinson, M.J., and Mergner, W.J., Studies on Platelet-derived
Growth Factor BB Gene Expression in the Intima in High- and Low-probability
Regions of Human Aorta. Modern Pathol 1995, 8, 478-482.
- Seidman, J.D., Borkowski, A., Aisner, S.C., and Sun, C.J.,
Rapid Growth of Pseudoangiomatous Hyperplasia of Mammary Stroma in
Axillary Gynecomastia in an Immunosuppressed Patient. Arch Pathol
Lab Med, 1993, 117, 736-738.
- Bennett, W.P., Colby, T.V., Travis, W.D., Borkowski, A., Jones,
R.T., Lane, D.P., Metcalf, R.A., Samet, J.M., Takeshima, Y., Gu, J.R.,
Vahakangas, K.H., Soini, Y., Paako, P., Welsh, J.A., Trump, B.F., and
Harris, C.C., P53 Protein Accumulates Frequently in Early Bronchial
Neoplasia. Cancer Res, 1993, 53, 4817-4822.
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