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Andrew A. Borkowski, M.D.
Associate Professor of Pathology and Cell Biology and Surgery
Chief, Molecular Diagnostics Laboratory
Department of Pathology and Cell Biology and Cell Biology
University of South Florida College of Medicine
12901 Bruce B. Downs, Blvd., MDC 11
Tampa, FL 33612-4799
Phone: (813) 972-2000 Ext. 6468

Andrew Borkowski

Year appointed: 2003

 
Affiliations:
Site/Title
-James A. Haley VA Hospital/
Chief,Molecular Diagnostics Laboratory
Pathology and Cell Biology and Cell Biology Service (673/113)
James A. Haley VA Hospital
13000 Bruce B. Downs Blvd.
Tampa, FL 33647

Qualification:
- M. D.
- Board certified in Anatomic and Clinical Pathology and Cell Biology by the American Board of Pathology and Cell Biology 

Expertise/ Research Interests:
- Advanced diagnostic technologies
- My main research interest involves investigation of molecular changes underlying prostate and urinary bladder neoplastic and non-neoplastic diseases with special emphasis on tumor proliferation and apoptotic processes. 
My recent publications on this topic are here

Other Expertise:

- Molecular and Advanced Diagnostics
- Surgical Pathology and Cell Biology and Cytology, with special expertise in Genitourinary and Gastrointestinal Pathology and Cell Biology.

Memberships:
- College of American Pathologists


Previous Positions:
- Assistant Professor of Pathology and Cell Biology and Urology
University of Maryland School of Medicine
22 South Greene Street, NBW43
Baltimore, MD 21201 
- Acting Chief, Pathology and Cell Biology and Cell Biology Service
Maryland VA Health Care System
10 North Greene Street
Baltimore, MD 21201 

Publications:

  1. Burke L, Flieder D.B., Guinee D.G., Brambilla E., Freedman A.N., Bennett W.P., Jones R.T., Borkowski A., Caporaso N.A., Fleming M., Trastek V., Pairolero P., Tazelaar H., Midthun D., Jett JR, Liotta L.A., Travis W.D., Harris C.C. Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma. Clin Cancer Res 2005, 11:232-41.
  2. Alexander, R.B., Mann D.L., Borkowski, A.A., Fernandez-Vina, M., Klyushnenkova, E.N., Kodak, J., Propert, K.J., Kincaid, M. Granulomatous Prostatitis Linked to HLA-DRB1*1501. J Urol 2004, 171:2326-2329.
  3. Kimos, M.C., Wang, S., Borkowski, A., Yang, G.Y., Perry, K., Olaru, A., Deacu, E., Sterian, A., Cottrell, J., Papadimitriou, J., Sisodia, L., Selaru, F.M., Mori, Y., Xu, Y., Yin, J., Abraham, J.M., Meltzer, S.J. Esophagin And Proliferating Cell Nuclear Antigen (PCNA) Are Biomarkers of Human Esophageal Neoplastic Progression. Int J Cancer 2004, 111:415-417.
  4. Borkowski, A., Lee, D.H., Sydnor, D.L., Johnson, R.J., Rabinovitch, A., Moore, G.W. Intranet-Based Quality Improvement Documentation at the Veterans Affairs Maryland Health Care System. Modern Pathol 2001, 14:1-5. 
  5. Winter, R.N., Kramer, A., Borkowski, A., Jacobs, S.C., Kyprianou, N. Loss of Caspase-1 and Caspase-3 Protein Expression in Human Prostate Cancer. Cancer Res 2001, 61:1227-32. 
  6. Keledjian, K., Borkowski, A., Kim, G., Isaacs, J.T., Jacobs S.C., Kyprianou, N. Reduction of Human Prostate Tumor Vascularity by alpha 1-Adrenoceptor Antagonist Terazosin. Prostate 2001, 48:71-8. 
  7. Glassman, D.T., Chon, J.K., Borkowski, A., Jacobs, S.C., Kyprianou, N. Combined Effect of Terazosin and Finasteride on Apoptosis, Cell Proliferation and Transforming Growth Factor-b Expression in Benign Prostatic Hyperplasia. Prostate 2001, 45:1-7. 
  8. Guo, Y., Borkowski, A., Sigman D.B., Kuprianou, N., Racial Differences in Prostate Cancer Growth: Apoptosis and Cell Proliferation in Caucasian and African-American Patients. Prostate 2000, 42, 130-6. 
  9. Chon, J.K., Borkowski, A., Partin, A.W., Isaacs, J.T., Jacobs, S.C., Kyprianou, N. a1-adrenoceptor Antagonists Terazosin and Doxazosin Induce Prostate Apoptosis without Affecting Cell Proliferation in Patients with Benign Prostatic Hyperplasia. J Urology 1999, 161, 2002-8. 
  10. Del Pizzo, J.J., Borkowski, A., Jacobs, S.C., Kyprianou, N. Loss of Cell-cycle regulators p27Kip1 and Cyclin E in Transitional Cell Carcinoma of the Bladder Correlates with Tumor Grade and Patient Survival. Am J Pathol 1999, 155, 1129-1136. 
  11. Mackey, T.J., Borkowski, A., Jacobs, S.C., Amin, P., Kyprianou, N. Bcl-2/Bax Ratio as a Predictive Marker for Therapeutic Response to Radiation in Prostate Cancer Patients. Urology 1998, 52, 1085-1090. 
  12. Kyprianou, N., Litvak, J.P., Alexander, R.B., Borkowski, A., Jacobs, S.C., Induction of Prostate Apoptosis by Doxazosin in Benign Prostatic Hyperplasia. J Urology 1998, 159, 1810-1815. 
  13. Bennett, W.P., El-Deiry, W.S., Guinee, D.G., Freedman, A.N., Rush, W.L., Caporaso, N.E., Welsh, J.A., Jones, R.T., Borkowski, A., Travis, W.D., Fleming, M.V., Colby, T.V., Trastek, V., Pairolero, P.C., Tazelaar, H.F., Midthun, D., Jett, J.R., Liota, L.A., Vogelstein, B., Harris, C.C. p53/p21waf1/cip1 and Transforming Growth Factor-ß1 Protein Expression Correlate with Survival in Non-Small Cell Lung Cancer. Clin Cancer Res 1998, 6, 1499-1506. 
  14. Greenblatt, M.S., Feitelson, M.A., Zhu, M., Bennett, W.P., Welsh, J.A., Jones, R.T., Borkowski, A., and Harris, C.C., Integrity of p53 in Hepatitis B x Antigen-positive and -negative Hepatocellular Carcinomas. Cancer Res 1997, 57, 426-432. 
  15. Guo, Y., Sklar, G.N., Borkowski, A., Kuprianou, N., Loss of the Cyclin-dependent Kinase Inhibitor p27kip1 Protein in Human Prostate Cancer Correlates with Tumor Grade. Clin Cancer Research 1997, 3, 2269-2274. 
  16. Tu, H., Jacobs, S.C., Borkowski, A., and Kyprianou, N., Incidence of Apoptosis and Cell Proliferation in Prostate Cancer: Relationship with TGF-b and bcl-2 Expression. Int J Cancer 1996, 69, 357-363. 
  17. Sawyer, R., Berman, J.J., Borkowski, A., and Moore, G.W., Elevated PSA (Prostate Specific Antigen) Levels in African-American and White Men. Modern Pathol 1996, 9, 1029-1032. 
  18. Borkowski, A., Bennett, W.P., Jones, R.T., Borkowski, P., Harris, C.C., Ferreira, L.R., Kao, G.F., and Trump, B.F., Quantitative Image Analysis of p53 Protein Accumulation in Keratoacanthomas. Am J Dermatopathol 1995, 17, 335-338. 
  19. Borkowski, P., Kusiak, J.W., Borkowski, A., Liu, L., Smialek, J.E., Robinson, M.J., and Mergner, W.J., Studies on Platelet-derived Growth Factor BB Gene Expression in the Intima in High- and Low-probability Regions of Human Aorta. Modern Pathol 1995, 8, 478-482. 
  20. Seidman, J.D., Borkowski, A., Aisner, S.C., and Sun, C.J., Rapid Growth of Pseudoangiomatous Hyperplasia of Mammary Stroma in Axillary Gynecomastia in an Immunosuppressed Patient. Arch Pathol Lab Med, 1993, 117, 736-738. 
  21. Bennett, W.P., Colby, T.V., Travis, W.D., Borkowski, A., Jones, R.T., Lane, D.P., Metcalf, R.A., Samet, J.M., Takeshima, Y., Gu, J.R., Vahakangas, K.H., Soini, Y., Paako, P., Welsh, J.A., Trump, B.F., and Harris, C.C., P53 Protein Accumulates Frequently in Early Bronchial Neoplasia. Cancer Res, 1993, 53, 4817-4822.