Qualifications:
- Medical Director of Tissue Procurement and Gross Room Surgical Pathology and Cell Biology Staff

Expertise/ Research Interests:
- Expert in Gastrointestinal Pathology and Cell Biology. Molecular mechanisms of transformation and apoptosis. Microarray analysis.
- Research Interests include "Importance of the insulin-like growth factor I-receptor (IGFI-R) in cell transformation and tumor progression, with particular emphasis on colorectal, ovarian and prostatic adenocarcinoma." These studies involve the application of antisense strategies to in vitro and in vivo models of tumorigenicity and tumor metastasis. Dr. Coppola's second research interest is the study of CD44 expression in tumor metastases.

Other Expertise:
- Expert in guideline for collection and processing of tissues for Tissue Procurement

Memberships:
- Fellow of the American Society of Clinical Pathology and Cell Biology, 1995 - present
- Fellow of the College of American Pathologists, 1995 - present
- Member of the United States and Academy of Pathology and Cell Biology, 1995 - present
- Member of the Friends and Alumni Society of the Armed Forced Institute of Pathology and Cell Biology, 1996 - present
- Member of the Florida West Coast Association of Pathologists, 1995 - present
- Secretary of the Florida West Coast Association of Pathologists, 2000- present
- Member of the Association of Clinical Scientists, 1998 - 2000
- Member of the American Association for the Advancement of Science, 1998 - present
- Member of the New York Academy of Sciences, 1999 - present
- Member of the American Association for Cancer Research, 2000 - present

Publications:

1. Cowper S., Fiorica JV., Nicosia SV., and Coppola D. Case report: Vaginal papillary squamous cell carcinoma. Cancer Control 5:179-183, 1998.
2. Choudhry U., Boyce H.W., Coppola D. Proton pump inhibitor associated gastric polyps: retrospective analysis of their frequency, endoscopic and histological characteristics, and their clinical significance. Am J Clin Pathol 5:615-621, 1998.
3. Coppola D, Hyacinthe M, Fu L, Cantor A, Karl R, Marcet G, Cooper DL, Nicosia SV, Cooper HS. CD44V6 expression in human colorectal carcinoma. Human Pathol 29:627-635, 1998.
4. Hyacinthe M, Karl R, Coppola D, Goodgame T, Redwood W, Goldenfard P, Ohori NP, Marcet J. Squamous cell carcinoma of the pelvis in a giant condyloma acuminatum: use of neoadjuvant chemoradiation and surgical resection. Dis Colon and Rectum 41:1450-1453, 1998.
5. Coppola D, Lu L, Fruehauf J, Kyshtoobayeva A, Karl R, Nicosia SV, Yeatman T. Immunohistochemical analysis of p53, p21,WAF1 and TGF-?1 in human ductal adenocarcinoma of the pancreas: TGF-b1 protein expression is a predictor of longer survival. Am J Clin Pathol, 110:16-23,1998.
6. Coppola D., Fu L., Nicosia SV., Kounelis S., and Jones M. Prognostic significance of P53, vimentin and S100 protein-positive Langerhans cells in endometrial carcinoma. Hum Pathol 29:455-462, 1998.
7. Iravani S, Mao W, Fu L, Jove R, Yeatman TJ, Karl R, Coppola D. Elevated c- Src protein expression is an early event in colonic neoplasia. Laboratory Investigation 78:365-371,1998.
8. Thomas JG, Sundman D, Greene JN, Coppola D, Lu L, Sandin RL, Robinson L. A lung nodule, malignancy vs. The dog heartworm. Infections in Medicine 15:105-109, 1998.
9. Hyacinthe M, Jaroszeski MJ, Dang VV, Coppola D, Karl RC, Gilbert RA, Heller R. Electrically enhanced drug delivery for the treatment of soft tissue sarcoma. Cancer 85:409-417, 1999.
10. Coppola D, Schreiber RH, Mora L, Dalton W, Karl R. Significance of Fas and retinoblastoma protein expression during the progression of Barrett's metaplasia to adenocarcinoma. Ann Surg Oncol. 1999 Apr-May;6(3):298-304.
11. Irby RB, Mao W, Coppola D, Kang J, Trudeau W, Loubeau JM, Karl R, Fujita DJ, Jove R, Yeatman TJ. Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet. 1999 Feb;21(2):187-90.
12. Coppola D, Karl RC. Barrett's esophagus and Barrett's associated neoplasia: etiology and pathologic features. Cancer Control 6(1): 21-27, 1999.
13. Coppola D, Catalano E, Nicosia SV. Significance of p53 and Bcl-2 protein expression in human breast ductal carcinoma. Cancer Control 6(2): 181-187, 1999.
14. Hakam A, Yeatman TJ, Lu L, Mora L, Marcet G, Nicosia SV, Karl R, Coppola D. Expression of insulin-like growth factor - 1 receptor in human colorectal cancer. Hum Pathol 1999 Oct;30(10):1128-33.
15. Coppola D, Saunders B, Fu L, Mao W, Nicosia SV. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer Res. 1999 Jul 1;59(13):3264-70.
16. Coppola D. Tumor markers of radiation sensitivity. Cancer Control 6(4):385-392, 1999.
17. Kounelis S, Kapranos N, Kouri E, Coppola D, Papadaki H, Jones MW. Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. Mod Pathol 2000 Apr;13(4):379-88.
18. Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol 2000 Jan;20(1):139-48.
19. Niu G, Heller R, Catlett-Falcone R, Coppola D, Jaroszeski M, Dalton W, Jove R, Yu H. Gene therapy with dominant negative STAT3 inhibits growth of the murine melanoma B16 tumor. Cancer Res 59, 5059-63, 1999.
20. Coppola D, Lu L, H.W.Boyce . Chronic esophagitis dissecans presenting with esophageal strictures - a case report. Hum Pathol. Oct;31(10):1313-1317, 2000.
21. Zhang X, Wharton W, Donovan M, Coppola D, Croxton R, Cress WD, Pledger WJ. Density-dependent growth inhibition of fibroblasts ectopically expressing p27KIP1 Mol Biol Cell 2000 Jun;11(6):2117-2130.
22. Karl RC, Schreiber R, Boulware D, Baker S, Coppola D. Factors Affecting Morbidity, Mortality, and Survival in Patients Undergoing Ivor Lewis Esophagogastrectomy. Ann Surg 2000 May;231(5):635-643.
23. Kocab MA, Coppola D, Hiotis S, Karl RC, Barthel JS. Captopril-Associated Cholestasis Complicating the Management of Pancreatic Cancer. Surg Endosc 2000 Jul;14(7):681.
24. Yuan ZJ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 2000 May;19(19):2324-2330.
25. Coppola D. Molecular markers of pancreatic neoplasia. Cancer Control 7(5):421-427, 2000.
26. Heller L, Jaroszeski MJ, Coppola D, Pottinger C, Gilbert R, Heller R. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Ther 2000 May;7(10):826-9.
27. Blaskovich MA, Lin Q, Delarue FL, Sun J, Park HS, Coppola D, Hamilton AD, Sebti SM. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nat Biotechnol 2000 Oct;18(10):1065-70.
28. Zhang H, Wei S, Sun J, Coppola D, Zhong B, Wu GD, Goodwin B, Sebti S, Djeu J, Blanck G. Retinoblastoma protein activation of interleukin-8 expression inhibits tumor cell survival in nude mice. Cell Growth Differ, 2000; 11:635-639.
29. Nakshabendi IM, Maldonado ME, Coppola D, Mamel JJ. Esophageal Cast: A Manifestation of Graft-versus-Host Disease. Dig Dis 2000;18(2):103-105.
30. Jaroszeski MJ, Coppola D, Pottinger C, Benson K, Gilbert RA, Heller R. Treatment of hepatocellular carcinoma in a rat model using electrochemotherapy. Eur J Cancer 2001 Feb;37(3):422-30.
31. Jaroszeski MJ, Coppola D, Nesmith G, Pottinger C, Hyacinthe M, Benson K, Gilbert R, Heller R. Effects of electrochemotherapy with bleomycin on normal liver tissue in a rat model. Eur J Cancer 2001 Feb;37(3):414-21.
32. Sun J, Nam S, Lee CS, Li B , Coppola D, Hamilton A, Dou QP, Sebti SM. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Res 61; 1280-1284, 2001.
33. Kim CJ, Yeatman T, Coppola D, Trotti A, Williams B, Barthel JS, Dinwoodie W, Karl RC, Marcet J. Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann Surg. 2001 Sep;234(3):352-9.
34. Eason DD, Coppola D, Livingston S, Shepherd AT, Blanck G. Loss of MHC class II inducibility in hyperplastic tissue in Rb-defective mice. Cancer Lett. 2001 Oct 10;171(2):209-14.
35. Naidu KA, Tang JL, Naidu KA, Prockop LD, Nicosia SV, Coppola D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor 1 receptor (IGF1-R) expression. J Neurooncol. 2001 Aug;54(1):15-22.
36. Nackley II J, Barthel J, Coppola D. Upper gastrointestinal bleeding from leukemic gastric implants. Endoscopy. 2002 Apr;34(4):354.
37. Agrawal D, Chen T, Irby R, Quackenbush J, Chambers AF, Szabo M, Cantor A, Coppola D, Yeatman TJ. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst. 2002 Apr 3;94(7):513-21.
38. Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN. Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti- inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci. 2002 Mar 15;22(6):2246-54.
39. Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002 Mar 27;21(13):2000-8
40. Lucas ML, Heller L, Coppola D, Heller R. IL-12 Plasmid Delivery by in Vivo Electroporation for the Successful Treatment of Established Subcutaneous B16.F10 Melanoma.Mol Ther 2002 Jun;5(6):668-675.
41. Ouban A, Nawab RA, Coppola D. Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 cases. Clin Colorectal Ca, 1(4):243-248, 2002.
42. Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ. Inhibition of JNK by cellular stress- and TNFa-induced AKT2 through activation of the NFkB pathway in human epithelial cells. J Biol Chem. 2002 Jun 4 [epub ahead of print] .