Qualifications:
- M.D.

Expertise & Research Interests:
- Summary of Research:
HematoPathology and Cell Biology with special interest in acute leukemia and multiple myeloma, flow cytometric immunophenotyping and use of DNA probes in diagnosis and monitoring of clonal hematologic disorders, active research interest in detectionof minimal residual disease, determination of new prognostic indicators, and adhesion proteins in acute myeloid leukemia and multiple myeloma.
- Techniques/methods:
Polymerase chain reaction, DNA sequencing, flow cytometry, immunohistochemistry, bone marrow culture.

Publications:

1. George P, Bali P, Cohen P, Tao J, Guo F, Sigua C, Vishvanath A, Fiskus W, Scuto A, Annavarapu S, Moscinski LC, Bhalla K: Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3. Cancer Res 64:3645-52, 2004
2. George P, Bali P, Annavarapu S, Scuto A, Fiskus W, Guo F, Sigua C, Sondarva G, Moscinski LC, Atadja P, Bhalla K: Combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 105:1768-76, 2005
3. Wu J, Cantor A, Moscinski LC: B2 integrins are characteristically absent in acute promyelocytic leukemia and rapidly upregulated in vivo upon differentiation with all-trans retinoic acid. Leuk Res 2006, June 7 [Epub ahead of print]
   
4. Moscinski LC, Hill B. Molecular cloning of a novel myeloid granule protein. J Cell Biochem. 1995,58:1-12
5. Moscinski LC, Trudeau WL, Fields KK, Elfenbein GJ. High sensitivity detection of minimal residual breast carcinoma using the polymerase chain reaction and primers for cytokeratin 19. Diagn Molec Pathol. In press. July 1995
6. Ballester OF, Moscinski LC, Lyman GH, Chaney JV, Saba HI, Spiers ASD, Klein C. High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood. 1994,83:1903-1908