Svitlana Garbuzova-Davis, Ph.D., D.Sc.
Ph.D., Biology, Kharkiv State University
Office: MDC 3159
E-Mail: sgarbuzo@hsc.usf.edu
Phone: (813) 974-3189
FAX: (813) 974-3078
Biographical Sketch
Interests
Modulation of host immune inflammatory system due to transplanted cells
Current Research
"Cord Blood in ALS: Replacement or Protection?" - NIH, STTR Phase I ($144, 366)
The goal of this project to determine whether a cord blood cell population can serve as a novel source of transplant cells to ameliorate behavioral deficit and extend lifespan in the G93A mouse model of ALS by providing neurotrophic/neuroprotective support of dying motor neurons.
"Treating Sanfilippo with Umbilical Cord Blood Stem Cells" - Children's Medical Research Foundation ($75, 000)
The goal of this project is to determine the existence of a stem cell population from umbilical cord blood, which can delivery of the deficient Naglu enzyme and reduce the accumulation of heparan sulfate, after administration into the systemic circulation of a mutant mice model of Sanfilippo syndrome type B.
"Minimally Modified Cord Blood to Treat ALS" - Florida High Tech Coridor ($129,750)
Description: The goal of this project is to determine the effectiveness of T-cell depleted fraction from umbilical cord blood in delaying disease symptoms and increasing lifespan of a mouse model of ALS.
"Cord Blood Volume-Reduced Nucleated Cells to Treat Sanfilippo" - Lauren's Hope Foundation ($25, 000)
The goal of this project is to determine the existence of cord blood volume-reduced cells, which can delivery of the deficient Naglu enzyme and reduce the accumulation of heparan sulfate, after administration into the systemic circulation of a mutant mice model of Sanfilippo syndrome type B.
Major Publications
Garbuzova-Davis S., Willing A.E., Desjarlais T., Davis C.D., Sanberg P.R. Transplantation of human umbilical cord blood cells benefits in animal model of Sanfilippo syndrome type III B. Stem Cells and Development. In press.
Chen N., Hudsion J. E., Walczak P., Misiuta I, Garbuzova-Davis S., Jiang L., Sanchez-Romas J., Sanberg P. R., Zigova T., Willing A. E. Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural. Stem Cells. In press.
Sanberg P. R., Willing A. E., Garbuzova-Davis S., Saporta S., G. Liu, Sanberg C. D., Bickford P. C., Klasko S. K., El-Bardi N. (2005) Umbilical cord blood-derived stem cells and brain repair. Ann. N.Y. Acad. Sci. 1049: 67-83.
Walczak P., Chen N., Hudson J.E. Willing A.E., Garbuzova-Davis S.N., Song S., Sanberg P.R., Sanchez-Ramos J., Bickford P.C., Zigova T. (2004) Do hematopoietic cells exposed to neurogenetic environment mimic properties of endogenous neural precursors? J. of Neuroscience Research. 76: 244-254.
Garbuzova-Davis S., Willing A.E., Zigova T., Saporta S., Justen E.B., Lane J.C., Hudson J.E., Chen N., Davis C.D., Sanberg P.R. (2003) Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. J Hematotherapy & Stem Cell research, 12(3): 255-270.
Kassed C.A., Willing A.E., Garbuzova-Davis S., Sanberg P.R., Pennypacker K.R. (2002) Lack of NF- B p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Experimental Neurology, 176: 277-288.
Willing A.E., Garbuzova-Davis S., Sanberg P.R., Saporta S. (2002) Routes of stem cell administration in the adult rodent. In T. Zigova, P.R. Sanberg, J. Sanchez-Ramos (Eds.). Neural Stem Cells: Methods and Protocols. (Vol.198) Humana Press, Totowa, NJ, 357-74.