William R. Gower , Ph.D.
Biographical Sketch | Interests | Current Research | Major Publications
Ph.D., Ohio State University
B.A., University of Delaware
Office:
E-Mail: wgower@hsc.usf.edu
Phone: (813) 972-2000 ext. 7961
FAX: (813) 978-5889
Biographical Sketch
Interests
Natriuretic peptide expression and function in the digestive tract
Pathways of communication between the cardiovascular system and the gastrointestinal tract
Current Research
Regulation of the synthesis and release of the gastrointestinal regulatory peptides, i.e. atrial peptides. Elucidation of the physiological and pathophysiological function of atrial peptides in the gut and cardiovascular system.
See the Cardiac Hormone Center site for more information.
Major Publications
Denham, D.W., Franz, M.G., Denham, W., Zervos, E.E., Rosemurgy, A.S., Norman, J., Gower, W.R. Directed antisense therapy confirms the role of protein kinase C-a in the tumorigenicity of pancreatic cancer. Surgery, 124:218-224, 1998.
Gower, W.R., Salhab, K.F., Foulis, W.L., Pillai, N, Bundy, J.R ., Vesely, D.L., Fabri, P.J., Dietz, J.R. Regulation of atrial natriuretic peptide gene expression in gastric antrum by fasting. Am J Physiol, 278(3):R770- R780, 2000.
Venkatasubbarao, K., Ahmed M.M., Mohiuddin, M., Swiderski, C., Lee, E., Strodel, W., McGrath, P., Gower, W.R., Salhab, K.F., Freeman, J.W. Down regulation of TGF-b receptors type II and III expression in pancreatic adenocarcinoma. Anti-Cancer Res., 20:43-51, 2000.
Gower, W.R., Sanberg, P.R., Brown, P.G., Salyani, S., Pasqual, C.J. McGrogan, M., Good, R.A. Engelman, R.W. hNT neurons express an immunosuppressive protein that blocks T-lymphocyte proliferation and interleukin-2 production. J Neuroimmunol, 125(1-2):103-113, 2002.
Gower, W.R., McCuen, R.W., Arimura, A., Coy, D.A., Dietz, J.R., Landon, C.S., Schubert, M.L. Reciprocal paracrine pathways link atrial natriuretic peptide and somatostatin secretion in the antrum of the stomach. Reg. Peptides, 110:101-106, 2003.