Bruce G. Lindsey, Ph.D.
Department of Physiology and Biophysics
Biographical Sketch | Interests | Current Research | Major Publications
Ph.D. University of Pennsylvania
B.A., Williams College
Biographical Sketch
Positions and Employment
- 1970 Summer Research at Mt. Desert Island Biological Laboratory
- 1974 - 1977 National Institutes of Health Postdoctoral Fellowship, University of Pennsylvania
- 1977 - 1983 Assistant Prof. of Physiology, University of South Florida Health Sciences Center
- 1983 - 1988 Associate Prof. of Physiology, USF HSC
- 1988 - Present Prof. of Physiology & Biophysics, USF HSC
- 1992 - 1996 Interim Chair, Department of Physiology and Biophysics, USF HSC
- 1996 - Present Chair, Department of Physiology & Biophysics, USF HSC
- 1997 - Present Prof. of Neuroscience, Founding Member, Neuroscience Program, USF HSC
- 1998 - 2000 Chair, Neuroscience Concentration Comm., Ph.D. in Medical Sciences Program, USF
- 2001 - 2003 Interim Vice-President for Research, USF
Other Experience
- 1982 - Present Referee editor for journals: Journal of Neuroscience, Journal of Neurophysiology, Journal of Physiology (London), Journal of Computational Neuroscience, Brain Research, Journal of Applied Physiology, Neuroscience, American Journal of Physiology, Experimental Brain Research. Experimental Neurology, Journal of Neuroscience Methods, Pediatric Research, Respiration Physiology, Neuroscience Letters.
- 1988 - Present Grant reviewer: National Science Foundation, Veterans Administration, American Heart Association, Wellcome Trust, NIH (Ad hoc member on various Study Sections and Special Emphasis Panels, 1988 -present), United States Civilian Research and Development Foundation.
- 1994 - 2002 Central Nervous System Section Steering Committee, American Physiological Society
- 1996 - Present Association of Chairs of Departments of Physiology
- 1996 - 1997 Committee on Committees, American Physiological Society (APS)
- 1996 - 1999 Chair, Central Nervous System Section Steering Committee, APS
- 1996 - 1999 Section Advisory Committee, APS
1996 - 1998 Nominating Committee, APS - 2000 - 2002 Awards Committee, APS
- 2005 - 2007 Long-Range Planning Committee, APS
- 2004-present USF College of Engineering Advisory Board
Honors
- 2004 Javits Neuroscience Investigator (MERIT) Award, NINDS, NIH
- 2004 Sigma Xi
- 1996 Elected Chair, Central Nervous System Section, American Physiological Society
- 1971-1974 University Fellow, University of Pennsylvania
- 1971 Connant Harrington Prize in Biology, Williams College
- 1972 Phi Beta Kappa
Interests
Neurophysiology
Neural control of breathing
Spike train analysis
Modeling of neural networks
Neural coding
Parallel information processing
Computation in the brain
Current Research
The goal of our research is to define the brain stem network through which multiple sensory modalities shape the respiratory motor pattern. In a project funded by an NINDS Javits Investigator (Merit) Award, our hypothesis is that pontine and medullary networks operate together to modulate the respiratory motor pattern in response to several stresses, including changes in blood pressure and stimulation of chemoreceptors that monitor oxygen and carbon dioxide in the blood. We use advanced multi-array recording technology and computational methods to measure the responses and dynamic associations of many neurons recorded simultaneously in medullary raphe nuclei, pontine respiratory group, and the Bötzinger-ventral respiratory group.
Numerical network simulations are also being used as a research tool in a collaborative project funded by the NSF-NIH Collaborative Research in Computational Neuroscience Program. This project brings together researchers from universities in five states to develop a unified model of the brainstem respiratory network. Simulated populations of respiratory neurons with realistic biophysical properties and computationally efficient large-scale simulations will be used to integrate current knowledge about complex and nonlinear systems, provide a framework to test and predict the consequences of defined perturbations, and generate testable hypotheses. Associated in vivo and in vitro neurophysiological and pharmacological experiments will test model-based hypotheses on sub-cellular, cellular, network and systems level mechanisms that transform the respiratory network during the transitions between eupnea and hyperventilation apnea, from eupnea to gasping, and during sleep and waking.
Major Publications
Lindsey, B. G., Segers, L. S. and Shannon, R. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. II. Evidence for inhibitory actions of expiratory neurons. Journal of Neurophysiology 57: 1101-1117, 1987.
Lindsey, B. G., Hernandez, Y. M., Morris, K. F., Shannon, R., and Gerstein, G. L. Respiratory related neural assemblies in the brain stem midline. Journal of Neurophysiology 67: 905-922, 1992.
Lindsey, B. G., Hernandez, Y. M., Morris, K. F., Shannon, R., and Gerstein, G. L. Dynamic reconfiguration of brain stem neural assemblies: Respiratory phase dependent synchrony versus modulation of firing rates. Journal of Neurophysiology 67: 923-930, 1992.
Balis, U. J., Morris, K. F., Koleski, J. and Lindsey, B. G. Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation. Biological Cybernetics 70: 311-327, 1994.
Lindsey, B. G., Segers, L. S., Morris, K. F., Hernandez, Y. M., Saporta, S. and Shannon, R. Distributed actions and dynamic associations in respiratory-related neuronal assemblies of the ventrolateral medulla and brainstem midline: Evidence from spike train analysis. Journal of Neurophysiology 72: 1830-1851, 1994.
Morris, K. F., Arata, A., Shannon, R., and Lindsey, B. G. Inspiratory drive and phase duration during carotid chemoreceptor stimulation in the cat: medullary neurone correlations. Journal of Physiology (London) 491: 241-259, 1996.
Lindsey, B. G., Morris, K. F., Shannon, R., and Gerstein, G. L. Repeated patterns of distributed synchrony in neuronal assemblies. Journal of Neurophysiology 78: 1714-1719, 1997.
Lindsey, B. G., Arata, A., Morris, K. F., Hernandez, Y. M., and Shannon, R. Medullary raphe neurones and baroreceptor modulation of the respiratory motor pattern in the cat. Journal of Physiology (London) 512: 863-882, 1998.
Li, Z., Morris, K. F., Baekey, D. M., Shannon R., and Lindsey, B. G. Multimodal medullary neurons and correlational linkages of the respiratory network. Journal of Neurophysiology 82: 188-201, 1999.
Shannon, R., Baekey, D. M., Morris, K. F., Li, Z. and Lindsey, B. G. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. Journal of Physiology (London) 525: 207-224, 2000.
Arata, A., Hernandez, Y. M., Lindsey, B. G., Morris, K. F., and Shannon, R. Transient configurations of baroresponsive respiratory-related brainstem neuronal assemblies in the cat. Journal of Physiology (London) 525: 509-530, 2000.
Chang, E., Morris, K. F., Shannon, R., and Lindsey, B. G. Repeated sequences of interspike intervals in baroresponsive respiratory related neuronal assemblies of the cat brainstem. Journal of Neurophysiology 84: 1136-1148, 2000
Morris, K. F., Shannon, R., and Lindsey, B. G. Changes in medullary neurone firing rates and synchrony following induction of respiratory long-term facilitation in the cat. Journal of Physiology (London) 532: 483-497, 2001.
Dick, T. E., Shannon, R. Lindsey, B. G., Nuding, S. C., Segers, L. S., Baekey, D. M., and Morris, K. F. Arterial pulse modulated activity is expressed in respiratory neural output. Journal of Applied Physiology published 10 March 2005,10.1152/japplphysiol.01124.2004.
Lindsey, B. G. and Gerstein, G. L. Two enhancements of the gravity algorithm for multiple spike train analysis. Journal of Neuroscience Methods In press, 2005.