Stanley J. Nazian, Ph.D.
Biographical Sketch | Interests | Current Research | Major Publications
Ph.D., Marquette University
Biographical Sketch
Interests
ANP secretion and related peptides
Treatment of hypertension using cellular transplants
Current Research
Dr. Nazian's research interests are broadly focused on the control of reproductive processes in the male with special emphasis on the interactions among the hypothalamus, anterior pituitary and testes. Historically, most of his work has involved the pubertal transition and the endocrine and neuroendocrine factors involved in the control of the onset of puberty and this remains a strong interest. Recent and current projects include studies of an immortalized cell line (GT1) to examine more directly the influence of various hormones, neurotransmitters and neuropeptides on the secretion of GnRH (LHRH); the role of the hormone leptin in male reproductive physiology and puberty; the influence of recently described kisspeptin (metastin) on GnRH secretion at puberty. Ongoing collaborations with individuals from the Department of Physiology & Biophysics as well as the Department of Anatomy are examining the cardiac hormone system and the secretion of insulin from a Sertoli cell/islet cell construc
Major Publications
Nazian, S.J., C.S. Landon, K.E. Muffly and D.F. Cameron. Opioid inhibition of adrenergic and dopaminergic but not serotonergic stimulation of luteinizing hormone releasing hormone release from immortalized hypothalamic neurons. Mol. Cell Neurosci. 5:642-648, 1994.
Skvorak, J.P., S.J. Nazian, and J.R. Dietz. Endothelin acts as a paracrine regulator of stretch induced atrial natriuretic peptide release. Am. J. Physiol. 269:R1093-R1098, 1995 .
Nazian, S.J., C.S. Landon and J.R. Dietz. Alterations in the opioid control of LHRH release from hypothalami isolated from aged male rats. J. Geront. Biol. Sci 53A:B191-B195, 1998.
Cameron, D.F., K.E. Muffly and S.J. Nazian. Development of Sertoli cell compentency in the peripubertal rat. J. Androl. 19:573-579, 1998.
Nazian, S.J. and D.F. Cameron. Temporal relation between leptin and various indices of sexual maturation in the male rat. J Androl. 20:487-491, 1999
Newman, M.B., S.J. Nazian, P.R. Sanberg, D.M. Diamond and R.D. Shytle. Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry (in Press).