E. Truitt Sutton, Ph.D.
Biographical Sketch | Interests | Current Research | Major Publications
Ph.D., University of South Florida
M.S., University of Georgia
Biographical Sketch
Interests
structural and functional studies of vascular endothelial dysfunction
endotoxic shock Alzheimer's disease microscopic and imaging analysis of signaling molecules
Current Research
Our research involves structural and functional studies of vascular endothelial dysfunction in septic shock and Alzheimer's disease. Using intravital and electron microscopy, primarily in the microcirculation, our research has focused on the endothelial damage found in septic shock and the related inflammatory processes involving cytokines and their interaction with nitric oxide. We have also found that vascular dysfunction can be induced by the Alzheimer's peptide, Amyloid-b, and have shown that inflammatory processes are involved in the endothelial damage in Alzheimer's disease.
Major Publications
Sutton, E.T., T. Thomas, M.W. Bryant, C.S. Landon, C.A. Newton and J.A.G. Rhodin. Amyloid-b peptide induced inflammatory reaction is mediated by the cytokines TNFa and IL-1. J. Submicrosc. Cytol. Pathol. 31:313-323, 1999.
Sutton, E.T., J. Norman, P.S. Rao, L.B. Graham, C.A. Newton and I.S. Richards. Pulmonary endothelial and epithelial integrity and neutrophil infiltration following endotoxin in interleukin-1 receptor knockout mice. Shock 13:117-125, 2000.
Price, J.M., X. Chi, G. Hellermann and E.T. Sutton. Physiological levels of b-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production. Neurological Res. 23:505-512, 2001.