Department of Psychiatry and Behavioral Medicine
USF Health

Jun Tan, M.D., Ph.D.
Robert A. Silver Chair in Developmental Neurobiology
Associate Professor
Director of Developmental Neurobiology Laboratory
Silver Child Development Center

Contact Information Developmental Neurobiology Laboratory
Silver Child Development Center
Department of Psychiatry & Behavioral Medicine
12901 Bruce B. Downs Blvd., MDC 102
Tampa, Florida 33612-4742
Telephone: (813) 974-9326
Fax: (813) 974-1130
E-mail: jtan@hsc.usf.edu
Education

- 1996-1998 Post-Doc., Immunology Program, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA
- 1994-1996 Post-Doc., Department of Medical Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 1990-1992 Ph.D., Immunology, Third Military Medical University, Chongqing, China
- 1987-1989 M.S., Human Genetics, Institute of Genetics of Fudan University, Shanghai, China
- 1978-1983 M.D. training (B.Ms.), Medicine, Third Military Medical University, Chongqing, China

 
Bio-sketch Download Dr. Tan's NIH Bio-sketch
 
Interests We are interested in developing the novel treatments for Alzheimer’s disease (AD) and other neurodegenerative disorders (HIV dementia). For this purpose, we have established transdermal and other alternative vaccines for AD in mouse models of the disease. In addition, we have discovered the natural compounds in promoting amyloid precursor protein (APP) α-secretase cleavage or inhibiting γ-secretase activity both in various cell systems and as well as in animal models. Moreover, we have analyzed the role of microglial activation in modulation of AD-like pathology in experimental animal modes following administration of human umbilical cord blood cells.
 
Publications
  1. Antoinette B, Giunta B, Obregon D, Nikolic W, Tian J, Sanberg C, Sutton D and Tan J.
    Peripheral biomarkers in Autism: sAPP-α as a probable key player in early diagnosis.
    Int J Clin Exp Med 1(4):338-44 (2008).
  2. Town T, Laouar Y, Pittenger C, Mori T, Szekely C, Tan J, Duman R and Flavell R.
    Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer's-like pathology.
    Nat Med 14(6):681-7 (2008).
  3. Zhu YY, Hou HY, Nikolic W, Bickford P, Giunta B and Tan J.
    CD45RB is a novel molecular therapeutic target to inhibit Aβ peptide-induced microglial MAPK activation.
    PLoS ONE 3(5):e2135 (2008).
  4. Nikolic WV, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle D, Giunta B, Morgan D, Town T and Tan J.
    Transcutaneous β-amyloid immunization of transgenic Alzheimer's mice reduces cerebral β-amyloid deposits without T-cell infiltration and microhemorrhage.
    Proc Natl Acad Sci USA 104:2507-2512 (2007).
  5. Obregon D, Rezai-Zadeh K, Zeng J, Shytle D, Town T and Tan J.
    ADAM10 activation is required for green tea EGCG-induced α-secretase cleavage of amyloid precursor protein.
    J Biol Chem 281 (24):16419-16427 (2006).
  6. Rezai-Zadeh K, Shytle D, Mori T, Hou H, Ehrhart J, Zeng J, Hardy J, Morgen D, Town T and Tan J.
    Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer's transgenic mice.
    J Neurosci 25 (38):8807-8814 (2005).
  7. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA and Mullan MJ.
    Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
    Nat Neurosci 5(12):1288-1293 (2002).
  8. Tan J, Town T, Mori T, Wu Y, DelleDonne A, Obregon D, Rojiani A, Flavell R, Mullan M.
    CD40 is expressed and functional on neuronal cells.
    EMBO J 21 (4):37224-37231 (2002).
  9. Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M.
    CD45 opposes β-amyloid peptide-induced microglial activation via inhibition of p44/42 MAPK.
    J Neurosci 20 (20):7587-7594 (2000).
  10. Tan J, Town T, Paris D, Mori T, Crawford F, Mattson M, Flavell R, Mullan M.
    The CD40-CD40L interaction leads to microglial activation after β-amyloid stimulation.
    SCIENCE 286 (17):2352-2355 (1999).
Honors/Awards
  1. Robert A. Silver Chair in Developmental Neurobiology (2007)
  2. Investigator-Initiated Award: Alzheimer Association (2003)
  3. Young Investigator Research Award, National Science Foundation of China, 1992
    Achievement Award for Science and Technology in China, 1994
  4. National Outstanding Oversea Young Scientist Award, National Science Foundation of China, 2002
  5. 2002 Principal Investigator-Alzheimer Association-IIRG-02-4064-Role of CD40L in Gliosis and Amyloidosis in Alzheimer Transgenic Mice